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1

Mesenchymal Stem Cells Secrete Immunologically Active Exosomes

Zhang, Bin, Yin, Yijun, Lai, Ruenn Chai, Tan, Soon Sim, Choo, Andre Boon Hwa, Lim, Sai Kiang

Journal:

Stem Cells and Development

Year:

2014

Language:

english

File:

PDF, 2.48 MB

english, 2014

2

Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury

Arslan, Fatih, Lai, Ruenn Chai, Smeets, Mirjam B., Akeroyd, Lars, Choo, Andre, Aguor, Eissa N.E., Timmers, Leo, van Rijen, Harold V., Doevendans, Pieter A., Pasterkamp, Gerard, Lim, Sai Kiang, de Klei

Journal:

Stem Cell Research

Year:

2013

Language:

english

File:

PDF, 1.10 MB

english, 2013

3

Mesenchymal stem cell exosome ameliorates reperfusion injury through proteomic complementation

Lai, Ruenn Chai, Yeo, Ronne Wee Yeh, Tan, Kok Hian, Lim, Sai Kiang

Journal:

Regenerative Medicine

Year:

2013

Language:

english

File:

PDF, 1.50 MB

english, 2013

4

Mesenchymal stem cell exosome: a novel stem cell-based therapy for cardiovascular disease

Lai, Ruenn Chai, Chen, Tian Sheng, Lim, Sai Kiang

Journal:

Regenerative Medicine

Year:

2011

Language:

english

File:

PDF, 1.48 MB

english, 2011

5

Mesenchymal stem cell exosomes

Lai, Ruenn Chai, Yeo, Ronne Wee Yeh, Lim, Sai Kiang

Journal:

Seminars in Cell & Developmental Biology

Year:

2015

Language:

english

File:

PDF, 274 KB

english, 2015

6

The diagnostic and prognostic potential of plasma extracellular vesicles for cardiovascular disease

Bank, Ingrid EM, Timmers, Leo, Gijsberts, Crystel M, Zhang, Ya-Nan, Mosterd, Arend, Wang, Jiong-Wei, Chan, Mark Y, De Hoog, Vince, Lim, Sai Kiang, Sze, Siu Kwan, Lam, Carolyn SP, De Kleijn, Dominique

Journal:

Expert Review of Molecular Diagnostics

Year:

2015

Language:

english

File:

PDF, 706 KB

english, 2015

7

Dietary phytochemical PEITC restricts tumor development via modulation of epigenetic writers and erasers

Park, Jung Eun, Sun, Yang, Lim, Sai Kiang, Tam, James P., Dekker, Matthijs, Chen, Hong, Sze, Siu Kwan

Journal:

Scientific Reports

Year:

2017

Language:

english

File:

PDF, 1.75 MB

english, 2017

8

MSC exosomes alleviate temporomandibular joint osteoarthritis by attenuating inflammation and restoring matrix homeostasis

Zhang, Shipin, Teo, Kristeen Ye Wen, Chuah, Shang Jiunn, Lai, Ruenn Chai, Lim, Sai Kiang, Toh, Wei Seong

Journal:

Year:

2019

Language:

english

File:

PDF, 3.13 MB

english, 2019

9

Mesenchymal stem cell exosomes enhance periodontal ligament cell functions and promote periodontal regeneration

Chew, Jacob Ren Jie, Chuah, Shang Jiunn, Teo, Kristeen Ye Wen, Zhang, Shipin, Lai, Ruenn Chai, Fu, Jia Hui, Lim, Lum Peng, Lim, Sai Kiang, Toh, Wei Seong

Journal:

Acta Biomaterialia

Year:

2019

File:

PDF, 1.71 MB

2019

10

An anemic patient with phenotypical β-thalassemic trait has elevated level of structurally normal β-globin mRNA in reticulocytes

Sai-Kiang Lim, Azhar bin Ali, Hai Yang Law, Ivy Ng, Maxey Chung Ming Chung, Szu-Hee Lee

Journal:

American Journal of Hematology

Year:

2000

Language:

english

File:

PDF, 747 KB

english, 2000

11

Increased renal hypertrophy in diabetic mice genetically modified at the haptoglobin locus

Rachel Miller-Lotan, Yehuda Herskowitz, Shiri Kalet-Litman, Farid Nakhoul, Doron Aronson, Roaa Zoabi, Roy Asaf, Ofer Ben-Izhak, Edmond Sabo, Sai-Kiang Lim, Heinz Baumann, Franklin G. Berger, Andrew P.

Journal:

Diabetes/Metabolism Research and Reviews

Year:

2005

Language:

english

File:

PDF, 99 KB

english, 2005

12

Haptoglobin reduces renal oxidative DNA and tissue damage during phenylhydrazine-induced hemolysis

Lim, Yew Koon, Jenner, Andrew, Ali, Azhar Bin, Wang, Yanping, Hsu, Stephen I-Hong, Chong, Siew Meng, Baumman, Heinz, Halliwell, Barry, Lim, Sai-Kiang

Journal:

Kidney International

Year:

2000

Language:

english

File:

PDF, 1.04 MB

english, 2000

13

Folic acid supplementation normalizes the endothelial progenitor cell transcriptome of patients with type 1 diabetes: a case-control pilot study

Olivia van Oostrom, Dominique PV de Kleijn, Joost O Fledderus, Mario Pescatori, Andrew Stubbs, Attie Tuinenburg, Sai Kiang Lim, Marianne C Verhaar

Journal:

Cardiovascular Diabetology

Year:

2009

Language:

english

File:

PDF, 715 KB

english, 2009

14

Enabling a robust scalable manufacturing process for therapeutic exosomes through oncogenic immortalization of human ESC-derived MSCs

Tian Sheng Chen, Fatih Arslan, Yijun Yin, Soon Sim Tan, Ruenn Chai Lai, Andre Boon Hwa Choo, Jayanthi Padmanabhan, Chuen Neng Lee, Dominique PV de Kleijn, Sai Kiang Lim

Journal:

Journal of Translational Medicine

Year:

2011

Language:

english

File:

PDF, 1.98 MB

english, 2011

15

PI3 K/Akt/mTOR-mediated translational control regulates proliferation and differentiation of lineage-restricted RoSH stem cell lines

Jianwen Que, Qizhou Lian, Reida M El Oakley, Bing Lim, Sai-Kiang Lim

Journal:

Journal of Molecular Signaling

Year:

2007

Language:

english

File:

PDF, 1.05 MB

english, 2007

16

Quinacrine abolishes increases in cytoplasmic phospholipase A2mRNA levels in the rat hippocampus after kainate-induced neuronal injury

Wei-Yi Ong, Xin-Rong Lu, Benjamin Ong, Lloyd A. Horrocks, Akhlaq A. Farooqui, Sai-Kiang Lim

Journal:

Experimental Brain Research

Year:

2003

Language:

english

File:

PDF, 161 KB

english, 2003

17

Deriving clinically compliant mescenchymal stem cells (MSC) from differentiated human ESCs and elucidating MSC paracrine proteome

Lian, Qizhou, Sze, Siu Kwan, de Kleijn, Dominique PV, Lye, Elia, Tan, Eileen Khia Way, Low, Teck Yew, Lee, Chuen Neng, Lee, Eng Hin, Lim, Bing, Lim, Sai Kiang

Journal:

Year:

2008

Language:

english

File:

PDF, 227 KB

english, 2008

18

Transcriptome Profiling of Human and Murine ESCs Identifies Divergent Paths Required to Maintain the Stem Cell State

Chia Lin Wei, Takumi Miura, Paul Robson, Sai-Kiang Lim, Xiu-Qin Xu, Mathia Yu-Chuan Lee, Sanjay Gupta, Lawrence Stanton, Yongquan Luo, Jacqui Schmitt, Scott Thies, Wei Wang, Irina Khrebtukova, Daixing

Journal:

Year:

2005

Language:

english

File:

PDF, 765 KB

english, 2005

19

Derivation of Clinically Compliant MSCs from CD105+, CD24− Differentiated Human ESCs

Qizhou Lian, Elias Lye, Keng Suan Yeo, Eileen Khia Way Tan, Manuel Salto-Tellez, Tong Ming Liu, Nallasivam Palanisamy, Reida Menshawe El Oakley, Eng Hin Lee, Bing Lim, Sai-Kiang Lim

Journal:

Year:

2007

Language:

english

File:

PDF, 1.13 MB

english, 2007

20

Derivation of functional insulin-producing cell lines from primary mouse embryo culture

Guo Dong Li, Ruihua Luo, Jiping Zhang, Keng Suan Yeo, Fei Xie, Eileen Khia Way Tan, Dorothée Caille, Jianwen Que, Oi Lian Kon, Manuel Salto-Tellez, Paolo Meda, Sai Kiang Lim

Journal:

Stem Cell Research

Year:

2009

Language:

english

File:

PDF, 1.44 MB

english, 2009

21

Generating mESC-derived insulin-producing cell lines through an intermediate lineage-restricted progenitor line

GuoDong Li, Ruihua Luo, Jiping Zhang, Keng Suan Yeo, Qizhou Lian, Fei Xie, Eileen Khia Way Tan, Dorothée Caille, Oi Lian Kon, Manuel Salto-Tellez, Paolo Meda, Sai Kiang Lim

Journal:

Stem Cell Research

Year:

2009

Language:

english

File:

PDF, 2.16 MB

english, 2009

22

Reduction of myocardial infarct size by human mesenchymal stem cell conditioned medium

Leo Timmers, Sai Kiang Lim, Fatih Arslan, Jeffrey S. Armstrong, Imo E. Hoefer, Pieter A. Doevendans, Jan J. Piek, Reida Menshawe El Oakley, Andre Choo, Chuen Neng Lee, Gerard Pasterkamp, Dominique P.V

Journal:

Stem Cell Research

Year:

2008

Language:

english

File:

PDF, 791 KB

english, 2008

23

Human mesenchymal stem cell-conditioned medium improves cardiac function following myocardial infarction

Leo Timmers, Sai Kiang Lim, Imo E. Hoefer, Fatih Arslan, Ruenn Chai Lai, Angelique A.M. van Oorschot, Marie Jose Goumans, Chaylendra Strijder, Sui Kwan Sze, Andree Choo, Jan J. Piek, Pieter A. Doevend

Journal:

Stem Cell Research

Year:

2011

Language:

english

File:

PDF, 771 KB

english, 2011

24

Expression of major HDL-associated antioxidant PON-1 is gender dependent and regulated during inflammation

Azhar bin Ali, Qian Zhang, Yew Koon Lim, Dong Fang, Leslie Retnam, Sai-Kiang Lim

Journal:

Free Radical Biology and Medicine

Year:

2003

Language:

english

File:

PDF, 284 KB

english, 2003

25

Analysis of deep sequencing microRNA expression profile from human embryonic stem cells derived mesenchymal stem cells reveals possible role of let-7 microRNA family in downstream targeting of Hepatic Nuclear Factor 4 Alpha

Winston Koh, Chen Tian Sheng, Betty Tan, Qian Yi Lee, Vladimir Kuznetsov, Lim Sai Kiang, Vivek Tanavde

Journal:

Year:

2010

Language:

english

File:

PDF, 1.19 MB

english, 2010

26

Cotransplantation of Ex Vivo Expanded and Unexpanded Cord Blood Units in Immunodeficient Mice Using Insulin Growth Factor Binding Protein-2–Augmented Mesenchymal Cell Cocultures

Li Ming Ong, Xiubo Fan, Pat Pak Yan Chu, Florence Pik Hoon Gay, Sudipto Bari, Justina May Lynn Ang, Zhihong Li, Jianzhu Chen, Sai Kiang Lim, Ralph Milford Bunte, William Ying Khee Hwang

Journal:

Biology of Blood and Marrow Transplantation

Year:

2012

Language:

english

File:

PDF, 1.15 MB

english, 2012

27

Nitric oxide synthesis is involved in arterial haptoglobin expression after sustained flow changes

Mirjam B Smeets, Gerard Pasterkamp, Sai-Kiang Lim, Evelyn Velema, Ben van Middelaar, Dominique P.V de Kleijn

Journal:

Year:

2002

Language:

english

File:

PDF, 147 KB

english, 2002

28

Hepatic expression of PPARα, a molecular target of fibrates, is regulated during inflammation in a gender-specific manner

E.Shyong Tai, Azhar bin Ali, Qian Zhang, Lih Ming Loh, Chee Eng Tan, Leslie Retnam, Reida Menshawe El Oakley, Sai-Kiang Lim

Journal:

Year:

2003

Language:

english

File:

PDF, 256 KB

english, 2003

29

Myocardial infarction in the C57BL/6J mouse: A quantifiable and highly reproducible experimental model

Manuel Salto-Tellez, Sing Yung Lim, Reida Menshawe El Oakley, Tiffany Pooi Ling Tang, Zakaria Ali Moh ALmsherqi, Sai-Kiang Lim

Journal:

Cardiovascular Pathology

Year:

2004

Language:

english

File:

PDF, 690 KB

english, 2004

30

Freund adjuvant induces TLR2 but not TLR4 expression in the liver of mice

Journal:

International Immunopharmacology

Year:

2003

Language:

english

File:

PDF, 118 KB

english, 2003

31

Phenotyping of an in Vitro Model of Ischemic Penumbra by iTRAQ-Based Shotgun Quantitative Proteomics

Datta, Arnab, Park, Jung Eun, Li, Xin, Zhang, Huoming, Ho, Zhi Shan, Heese, Klaus, Lim, Sai Kiang, Tam, James P., Sze, Siu Kwan

Journal:

Journal of Proteome Research

Year:

2010

Language:

english

File:

PDF, 1.97 MB

english, 2010

32

Elucidating the temporal dynamics of chromatin-associated protein release upon DNA digestion by quantitative proteomic approach

Dutta, Bamaprasad, Adav, Sunil S., Koh, Cheng Gee, Lim, Sai Kiang, Meshorer, Eran, Sze, Siu Kwan

Journal:

Journal of Proteomics

Year:

2012

Language:

english

File:

PDF, 1.85 MB

english, 2012

33

Generation of hybrid cell lines with endothelial potential from spontaneous fusion of adult bone marrow cells with embryonic fibroblast feeder

Jianwen Que, Reida Menshawe El Oakley, Manuel Salto-Tellez, Nathalie Wong, Dominique P. V. de Kleijn, Ming Teh, Leslie Retnam, Sai-Kiang Lim

Journal:

In Vitro Cellular & Developmental Biology - Animal

Year:

2004

Language:

english

File:

PDF, 1.81 MB

english, 2004

34

Gonadal effects on plasma ACE activity in mice

Yew Koon Lim, Leslie Retnam, Balasubramanian Bhagavath, Sunil K Sethi, Azhar bin Ali, Sai-Kiang Lim

Journal:

Atherosclerosis

Year:

2002

Language:

english

File:

PDF, 209 KB

english, 2002

35

AFP+, ESC-Derived Cells Engraft and Differentiate into Hepatocytes in Vivo

Yijun Yin, Yew Koon Lim, Manuel Salto-Tellez, Soon Chye Ng, Chyuan-Sheng Lin, Sai-Kiang Lim

Journal:

Year:

2002

Language:

english

File:

PDF, 415 KB

english, 2002

36

Exosomes for drug delivery — a novel application for the mesenchymal stem cell

Lai, Ruenn Chai, Yeo, Ronne Wee Yeh, Tan, Kok Hian, Lim, Sai Kiang

Journal:

Biotechnology Advances

Year:

2013

Language:

english

File:

PDF, 914 KB

english, 2013

37

Human Embryonic Stem Cell-Derived Mesenchymal Stem Cells as Cellular Delivery Vehicles for Prodrug Gene Therapy of Glioblastoma

Bak, Xiao Ying, Dang, Hoang Lam, Yang, Jingye, Ye, Kai, Lee, Esther X.W., Lim, Sai Kiang, Wang, Shu

Journal:

Human Gene Therapy

Year:

2011

Language:

english

File:

PDF, 655 KB

english, 2011

38

Metabolic Adaptation to a Disruption in Oxygen Supply during Myocardial Ischemia and Reperfusion Is Underpinned by Temporal and Quantitative Changes in the Cardiac Proteome

Li, Xin, Arslan, Fatih, Ren, Yan, Adav, Sunil S., Poh, Kian Keong, Sorokin, Vitaly, Lee, Chuen Neng, de Kleijn, Dominique, Lim, Sai Kiang, Sze, Siu Kwan

Journal:

Journal of Proteome Research

Year:

2012

Language:

english

File:

PDF, 3.53 MB

english, 2012

39

Mesenchymal stem cell: An efficient mass producer of exosomes for drug delivery

Yeo, Ronne Wee Yeh, Lai, Ruenn Chai, Zhang, Bin, Tan, Soon Sim, Yin, Yijun, Teh, Bao Ju, Lim, Sai Kiang

Journal:

Advanced Drug Delivery Reviews

Year:

2013

Language:

english

File:

PDF, 273 KB

english, 2013

40

Plasma biomarker discovery in preeclampsia using a novel differential isolation technology for circulating extracellular vesicles

Hian Tan, Kok, Sim Tan, Soon, Sze, Siu Kwan, Ryan Lee, Wai Kheong, Jack Ng, Mor, Kiang Lim, Sai

Journal:

American Journal of Obstetrics and Gynecology

Year:

2014

Language:

english

File:

PDF, 844 KB

english, 2014

41

Quantitative profiling of the rat heart myoblast secretome reveals differential responses to hypoxia and re-oxygenation stress

Li, Xin, Ren, Yan, Sorokin, Vitaly, Poh, Kian Keong, Ho, Hee Hwa, Lee, Chuen Neng, de Kleijn, Dominique, Lim, Sai Kiang, Tam, James P., Sze, Siu Kwan

Journal:

Journal of Proteomics

Year:

2014

Language:

english

File:

PDF, 938 KB

english, 2014

42

Microvesicle protein levels are associated with increased risk for future vascular events and mortality in patients with clinically manifest vascular disease

Kanhai, Danny A., Visseren, Frank L.J., van der Graaf, Yolanda, Schoneveld, Arjan H., Catanzariti, Louise M., Timmers, Leo, Kappelle, L. Jaap, Uiterwaal, Cuno S.P.M., Lim, Sai Kiang, Sze, Siu Kwan, Pa

Journal:

International Journal of Cardiology

Year:

2013

Language:

english

File:

PDF, 371 KB

english, 2013

43

A Comparative Study of Electrostatic Repulsion-Hydrophilic Interaction Chromatography (ERLIC) versus SCX-IMAC-Based Methods for Phosphopeptide Isolation/Enrichment

Gan, Chee Sian, Guo, Tiannan, Zhang, Huoming, Lim, Sai Kiang, Sze, Siu Kwan

Journal:

Journal of Proteome Research

Year:

2008

Language:

english

File:

PDF, 1.45 MB

english, 2008

44

Generation of Hybrid Cell Lines with Endothelial Potential from Spontaneous Fusion of Adult Bone Marrow Cells with Embryonic Fibroblast Feeder

Jianwen Que, Reida Menshawe El Oakley, Manuel Salto-Tellez, Nathalie Wong, Dominique P. V. de Kleijn, Ming Teh, Leslie Retnam and Sai-Kiang Lim

Journal:

In Vitro Cellular & Developmental Biology - Animal

Year:

2004

Language:

english

File:

PDF, 1.02 MB

english, 2004

45

Quantitative Profiling of Chromatome Dynamics Reveals a Novel Role for HP1BP3 in Hypoxia-induced Oncogenesis

Dutta, Bamaprasad, Yan, Ren, Lim, Sai Kiang, Tam, James P., Sze, Siu Kwan

Journal:

Molecular & Cellular Proteomics

Year:

2014

Language:

english

File:

PDF, 3.35 MB

english, 2014

46

Proteolytic Potential of the MSC Exosome Proteome: Implications for an Exosome-Mediated Delivery of Therapeutic Proteasome

Lai, Ruenn Chai, Tan, Soon Sim, Teh, Bao Ju, Sze, Siu Kwan, Arslan, Fatih, de Kleijn, Dominique P., Choo, Andre, Lim, Sai Kiang

Journal:

International Journal of Proteomics

Year:

2012

Language:

english

File:

PDF, 614 KB

english, 2012

47

Immunotherapeutic Potential of Extracellular Vesicles

Zhang, Bin, Yin, Yijun, Lai, Ruenn Chai, Lim, Sai Kiang

Journal:

Frontiers in Immunology

Year:

2014

Language:

english

File:

PDF, 1.33 MB

english, 2014

48

Delineating Biological Pathways Unique to Embryonic Stem Cell-Derived Insulin-Producing Cell Lines from Their Noninsulin-Producing Progenitor Cell Lines

Chen, Tian Sheng, Tan, Soon Sim, Yeo, Ronne Wee Yeh, Teh, Bao Ju, Luo, Ruihua, Li, GuoDong, Lim, Sai Kiang

Journal:

Year:

2010

Language:

english

File:

PDF, 473 KB

english, 2010

49

Whole bone marrow transplantation induces angiogenesis following acute ischemia

El Oakley, Reida Menshawe, Seow, Kok Kuan, Tang, Tiffany Pooi Ling, Kok, Chee Wai, Teh, Ming, Lim, Yean Teng, Lim, Sai-Kiang

Journal:

Year:

2002

Language:

english

File:

PDF, 409 KB

english, 2002

50

Dementia-linked amyloidosis is associated with brain protein deamidation as revealed by proteomic profiling of human brain tissues

Adav, Sunil S., Gallart-Palau, Xavier, Tan, Kok Hian, Lim, Sai Kiang, Tam, James P., Sze, Siu Kwan

Journal:

Molecular Brain

Year:

2016

Language:

english

File:

PDF, 1.81 MB

english, 2016